Monthly Archives: October 2011

PDE 5 Inhibitors may assist brain tumor treatment

According to the results of the study conducted in 2010, the oral medications for treatment of ED in men such as Cialis, Levitra and Viagra may back the brain tumor treatment effectiveness.

The supposition was supported by the data of the animal study involving mice with brain tumors tied to both lung and breast cancer. According to the study erectile dysfunction medications such as sildenafil (Viagra), tadalafil (Cialis) and vardenafil (Levitra) can empower the chemotherapy medication Herceptin to enter the blood-brain barrier (BBB). BBB separates the blood circulating in the body from the brain extracellular fluid (BECF). BBB naturally protects the brain from dangerous compounds thus making it hard for medications to enter into the brain. The cancer treatment must come through BBB to fight the cancer that has spread to the brain.

BBB obstructs the distribution of cancer treatment medication, especially such drug as Herceptin characterized by large-molecule formulation which makes it hard to penetrate the BBB. The researches supposed that erectile dysfunction drugs can increase the ability of the cancer medications to go through the brain barrier.

In treatment of brain cancers the difficulty is in the ability of the medications to reach the target – the tumor in the brain. When there are potent drugs which can help to fight the disease but there is no way of how to deliver these drugs to the brain, the possibility of using ED oral medications should be carefully considered as a solution.

The tested mice who had received ED medications have demonstrated 20% more survival cases that the mice that had not received Cialis online with Herceptin.

The amount of Herceptin that was able to get to brain tumors has doubled in mice who were administered ED medications in comparison with mice who were administered only Herceptin.

Cialis linked to long – term hearing loss

The erectile dysfunction oral medication Cialis, and other ED medications, may urge long-term hearing loss among men, according to the study conducted by the researchers from the University of Alabama at Birmingham.

The researchers studied the data which gives the ground to association between the onset of hearing problems and PDE -5 inhibitors. The study has analyzed the data of more than 11,500 men over the age of 40. The survey data had been accumulated by the federal Agency for Healthcare Research and Quality between 2003 and 2006.

The study was conducted after the resolution of the Food and Drug Administration (FDA) to make the manufacturers of PDE 5 inhibitors to put the warning labeling about hearing loss risks for such medications. This decision had roots in post marketing reports of sudden hearing loss among users of Cialis online and other similar drugs.

This authorized warning about hearing loss and the use of PDE 5 medications guarantees that patients using these medications be careful about the signs and symptoms of hearing impairment and stimulated to seek immediate medical attention in case potentially dangerous effects occur.

The researches after careful analysis of the data had come to the conclusion that men who took PDE5 inhibitors on a regular basis had twice the chance for developing hearing loss as those who did not.

Still they made an accent that more research is required, due to the fact that this class of drugs was originally developed and indicated for the treatment of pulmonary high blood pressure.

PDE 5inhibitors work by increasing blood flow to the penile tissues and the researchers postulated that this drug class may have the same effect on the ear tissues. They also supposed that this increased blood flow in the ear may result in hearing loss.

Cialis usage and STDs in men over 40

According to the recent studies conducted by the medical professionals from Massachusetts General Hospital and the University of Southern California those men who are being treated with ED oral therapies have increased rates of sexually transmitted diseases than those who do not take such medications. The researches were worried to know that men over 35-40 years suffering from ED are at increased risk to have HIV/AIDS, Chlamydia and other infectious diseases and alarm doctors to warn their patients about risk behaviors and safe sex. They say this happens because medical professionals do not tell the patients over 35-40 years about using condoms supposing that men in the age of over 30 years of old do know about safe sexual activity. However the statistics shows the other thing – men who take PDE 5 inhibitors risk their health having unsafe sex with other partners and tend to have polygamous relationships.

The study included about 34,000 males over 40 who used ED oral therapies and approximately1.37 million men over 40 who were non-users.

The results of the study have demonstrated that males who had been ordered an ED medication were two times more likely than non-users to have sexually transmitted diseases. The researchers suppose that the Cialis Online have nothing to do with increased STD risk, but the risk sex behaviors of men is the main factor resulting in higher rates of STDs in men. The researchers appeal to the doctors prescribing ED medications to alarm the patients about STDs risk of unsafe sex.